Journal of Traditional Medicines
Online ISSN : 1881-3747
Print ISSN : 1880-1447
ISSN-L : 1880-1447
Regular Article
Effect of a traditional Chinese medicine, maobushisaishinto, on the antibody titer after influenza vaccination:
A randomized, placebo-controlled, double-blind trial
Yoshihiro TERASHIMAKei HAMAZAKIMiho ITOMURAMingming HUANNaotoshi SHIBAHARASatoru KOBAYASHITomohito HAMAZAKI
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JOURNAL FREE ACCESS

2007 Volume 24 Issue 2 Pages 59-66

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Abstract

Background: It was shown that a traditional Chinese medicine, maobushisaishinto (MBST), had adjuvant effects on influenza vaccination in an animal experiment and an open trial in elderly subjects.
Purpose: To examine the adjuvant effects of MBST in a closer clinical experiment.
Methods: Forty-seven healthy subjects between 20 and 71 y of age were randomly assigned to two groups (control and MBST groups) in a double-blind manner. The subjects in the MBST group (n=23) took 1.68g spray-dried powder of MBST/day for two weeks; the rest (control subjects, n=24) took the same amount of indistinguishable placebo. Then subjects were vaccinated against influenza viruses (A/H1N1, A/H3N2 and B). Serum hemagglutination inhibition titers were measured at weeks 0, 1, 2, 4, and 12.
Results: The titers against the three viruses were increased continuously for the first two weeks and leveled off. However, MBST was not superior to placebo in any titers.
Conclusion: We could not find any adjuvant effects of MBST in this experimental condition.

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© 2007 Medical and Pharmaceutical Society for WAKAN-YAKU
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