On the Kynureninase -Medico-histolical aspect of tryptophan metabolism with emphasis on the action of taurin and Zn²⁺ to diabetic rats-

Abstract

In 1925, Kynurenin has discovered by Matsuoka and Yoshimatsu and was named as Kynurenin by Prof. Yashiro Kotake.

Since then, these metabolites have experimented by Yashiro Kotake, Yahito Kotake, Y azo Kotake, K Ichihara and Osamu Hayaishi et al.

In this report, we display the action of taurine in diabetic rats through Kynureninase activity of rat liver.

And we discuss about the interrelationship between the structure of Kynureninase protein and cystathionine synthase or lyase, and also about the difference aganinst decarboxylase (5-OH Trp decarboxylase, DOPA decarboxylase and His decarboxylase protein related Zn²⁺ ion).