The Effects of Oyster ( Crassostrea gigas) Extract on Cell Proliferation and Antitumor Activity

Abstract

The effects of oyster extract on tumor cells were studied using three cell lines (mice myeloma cell and A31 and SV-T2 cells originated from Balb/c 3T3 cell) and mice inoculated with P388 leukemia. Hot water extract was cytostatic against A31 cell ,and SV-T2 cell, but not against myeloma cell. And the high molecular weight fraction inhibited slightly the proliferation of myeloma cell and SV-T2 cell, but not of A31 cell. The Low molecular weight fraction were cytostatic against these three cells. On mice With P388 leukemia, the high and low molecular weight fractions were more effective in prolonging life than hot water extract.