Antidiabetic Zinc (II) Complexes with Amide Derivative Compounds

Abstract

Zn(II) complexes with amide derivative ligands exhibited the in vitro insulinominetic activities in isolated rat adipocytes treated with epinephrine in terms of inhibition of free fatty acid release. It was found that the blood glucose levels are normalized by daily intraperitoneal injection of Zn(II) complexes with 2-picolinamide(pa-a) and 6-methyl-2-picolinemethylamide(6mpa-ma) for 14 days in KK-A^y mice who are a model animal with hereditary type 2 diabetes mellitus (DM). After the administrations of the complexes for 14 days, improvement of the glucose metabolisms was confirmed by an oral glucose tolerance test. In addition, the hemoglobin A_1c, which shows the average blood glucose levels over a long period, was improved. Based on the results, Zn(II)-picolinamide derivative complexes are proposed to be a possible therapeutic agent to treat type 2 DM.