Effect of hyperbaric oxygen on Zinc deficiency rats

Abstract

To examine the effect of hyperbaric oxygen on Zinc (Zn) deficient rats, we investigate the morphological changes and expression of inducible nitric oxide synthese (iNOS) and ED1 in lung of rats after hyperbaric oxygen exposure. Seven-weeks-old male Spreague-Dawley (SD) rats were fed on diets supplemented 0 or 0.02% Zn for 60 days. They were exposed to 2.8 ata for 60 minutes by 100% oxygen and examined pathohistological changes and expression of iNOS and EDI in lung. In 0% Zn diet, sever morphological changes and strong expression of iNOS and EDI were found. However, number of (WBC) did not increase in 0% Zn diet. These results suggest that the hyperbaric oxygen stress causes sever lung injury in Zn deficiency compared to normal condition.