Anti-cancer effect of tocotrienol and its mechanism

Abstract

Angiogenesis is a complex process of sprouting new capillaries from the pre-existing blood vessels. It happens in normal physiological processes, such as embryonic development, the female menstrual cycle, bone remodeling and wound healing. On the other hand, angiogenesis also plays a crucial role in many pathological conditions, including tumor growth, diabetic retinopathy, psoriasis, rheumatoid arthritis and atherosclerosis. Here the antiangiogenic effect of rice bran tocotrienol (T3) and its mechanism from the fundamental data of in vitro cell studies, DNA chip analysis, and in vivo egg and animal models are described.