Effect of Dietary Vitamin B₆ on Blood Selenium Level and GIutathione Peroxidase Activity in Rats

Abstract

Effect of dietary vitamin B₆ on blood selenium level and glutathione peroxidase activity was carried out. Male Wistar 12-week-old rats were fed a vitamin B₆-selenium-deficient basal diet for three weeks, and then the rats were divided into six groups. One group was fed the basal diet, the others were fed the diet supplemented with 250μg vitamin B₆ / 100g as pyridoxine • HCl, or with 0.25mg selenium/ kg as Na₂SeO₃ or DL-selenomethionine, or with vitamin B₆ and selenium for 12weeks. vitamin B₆ status had not significant effect on plasma selenium and glutathione peroxidase levels, however, selenium content and gultathione peroxidase activity in erythrocytes were significantly higher in vitamin B₆-supplemented groups than in vitamin B₆-deficient groups, regardless of the form of selenium. These results suggest that the utilization of selenium for erythrocytes was dependent vitamin B₆ status.