The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Original Article
Microarray analysis of differentially expressed gene responses to bisphenol A in Arabidopsis
Yong-Sheng TianXiao-Fen JinXiao-Yan FuWei ZhaoHong-Juan HanBo ZhuMan- LiuQuan-Hong Yao
著者情報
キーワード: Arabidopsis, Microarray, RT-PCR, BPA, Toxicity
ジャーナル フリー
電子付録

2014 年 39 巻 4 号 p. 671-679

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抄録

Environmental levels of bisphenol A (BPA) are a global concern because the compound can cause damage to reproductive organs, the thyroid gland, and brain tissues at developmental stages. Plants are important in removing BPA from the atmosphere, soil, and water. However, knowledge on the mechanism by which plants respond to this compound is limited. To determine the response mechanism of plants to BPA, we used a microarray system to analyze the gene expression patterns of Arabidopsis thaliana after irrigation with 3.0 mM BPA. We identified 651 genes that were differentially expressed upregulated and 470 genes that were downregulated by BPA. These genes may specifically contribute to BPA uptake, transformation, conjugation, and compartmentation in plants. The potential function of upregulated genes in plant defense against BPA was also determined.

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© 2014 The Japanese Society of Toxicology
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