The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
TWENTY-EIGHT WEEK TOXICITY STUDY OF PERLITE POWDER IN MICE
Takeo SAKAISoshichi NAGAO
著者情報
キーワード: mouse
ジャーナル フリー

1985 年 10 巻 2 号 p. 83-93

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抄録
Groups of 21 male and 21 female mice were given diets containing 20%, 10%, 1% or 0%(control) perlite for 28 weeks. Appearance, behavior, mortality, and food consumption of mice of treated groups were not affected during the experimental period. Males of the 20% and 10% groups did experience slightly reduced growth rate. No significant drug-related changes were found in urinalysis, hematology, serum chemistry, and organ weight. No differences were found between control and treated groups in autopsy and histopathological findings. Therefore, the maximum no-effect level is considered to be 1% in the diet which developed no toxic changes in any items examined in mice treated orally with perlite for 28 weeks.
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© The Japanese Society of Toxicology Headquarters
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