The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
STUDY ON THE METABOLISM OF VOLATILE HYDROCARBONS IN MICE : PROPANE, n-BUTANE, AND iso-BUTANE
Shojiro TSUKAMOTOShoetsu CHIBAToru MUTOTadaaki ISHIKAWAMasao SHIMAMURA
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Keywords: liver microsomes
JOURNAL FREE ACCESS

1985 Volume 10 Issue 4 Pages 323-332

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Abstract
A study was conducted to establish whether volatile hydrocarbons, such as propane, n-butane and iso-butane, are metabolized in mice or not. In mice having inhaled these gases, isopropanol and acetone were yielded from propane, sec-butanol and methyl ethyl ketone from n-butane, and tert-butanol from iso-butane as the respective metabolites. In addition, liver microsomes were found to contain the enzymic system participating in these metabolisms. In vitro reactions with liver microsomes produced isopropanol from propane, sec-butanol from n-butane, and tert-butanol from iso-butane. It was assumed that hydrocarbons were first converted to (ω-1)-alcohols by microsomal enzyme system and then to corresponding ketones by alcohol dehydrogenase.
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