RELATIONSHIP BETWEEN ARRHYTHMIAS AND A LIBERATION OF ENDOGENOUS CATECHOLAMINE CAUSED BY TOXIC DOSES OF OUABAIN IN DOGS.

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A remarkable blood pressure rise associated with elevated plasma catecholamines was observed at the onset of arrhythmia when a toxic dose of ouabain was administered into dogs. The mechanism of this phenomenon may be explained as the release of endogenous catecholamines from the adrenal glands and peripheral sympathetic nerve endings brought about by a toxic dose of ouabain. Central catecholamine does not appear to be related with the above phenomenon.