COMPARATIVE STUDIES ON POSTNATAL DEVELOPMENT OF LIVER β-GLUCURONIDASE ACTIVITY BETWEEN GUNN RATS AND WISTAR RATS

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The β-glucuronidase activity in liver of Wistar strain albino rats shows a sharp increase in 2-3 days after birth and indicates no longer extensive alterations in 50-90 days, after reaching the peak in about 20-30 days. In Gunn strain rats, the activity was detected to be low, as compared to that in Wistar strain albino rats. In kidney and intestine, the activity was observed in 12 days after birth or thereafter, but it was maintained at a certain level. In the study using Wistar strain albino rats, the β-glucuronidase activity showed an increase in liver, kidney and intestine at 500 mg/kg borneol oral administration. The same increase was noticed only in liver at 50 mg/kg chloretone administration and also in liver at 300 mg/kg barbital-Na administration. In Gunn strain rats, no notable increase was indicated even in the administration of any drugs.