Abstract
A case of delayed Sumithion® (fenitrothion) intoxication is reported. A 52-year-old man ingested 10 ml of Sumithion® in order to commit suicide with alcohol and triazoram. Several hours later, he was admitted to our hospital because of clouding consciousness. On admission, he was somnolent, but had no other symptoms, especially suggested organophosphorus intoxication. After 40 hours, fasciculation and salivation, which are early symptoms of organophosphorus intoxication, gradually appeared. The concentration of Sumithion® in the blood was measured during the course and its metabolism was represented phalmacokineticaly by a 2-compartment model. The retarded metabolism of the Sumithion® was suggested by this model. It is considered that the retarded metabolism of Sumithion® caused the delayed intoxication.
