Triple drug Therapy for the Prevention of Early Acute Renal Allograft Rejection in Dogs

Abstract

A triple drug therapy with emulsified cyclosporine, mycophenolate mofetil and predonisolone was used for 90 days for the prevention of acute rejection in six renal transplanted beagles. Five dogs survived for 90 days, but one dog died suddenly from unknown reason with a functioning graft 9 days after transplantation. Allografts of three of the five survived dogs showed no evidence of acute rejection based on Banff'07 histopathological classification. The other two dogs showed acute allograft rejection on histopathological evaluation and urinary tract infection at the end of the study. None of the dogs showed adverse effects such as hepatotoxicity and myelosuppression. At necropsy, abnormal cystic dilatation of the crypts with secretory accumulation was found in the duodenum mucosa in all dogs survived for 90 days. With further research, this triple drug immunosuppressive therapy could become a potential alternative of the classical immunosuppressive protocol (cyclosporine, azathiopurine and predonisolone) for the prevention of acute allograft rejection in dogs.