In the present paper, the possibility of clinical use of Xylazine in the anesthesia of dog and cat was discussed based upon experiments with overdose of Xylazine and upon clinical use of Xylazine-Ketamine hydrochloride combination and of Xylazine-Pentobarbital sodium combination in dogs and cats.
Administration of 9 mg/kg (about three times of usually recommended dose as anesthetics) of Xylazine through various routes was proved at least not to be fatal as far as clinical manifestations are concerned, as all animals could tolerate this dosage without any serious troubles.
Since, even with quite high dosage of Xylazine as high as 9 mg/kg, deep anesthesia could not be obtained, Xylazine was used in combination with Ketamine hydrochloride and with Pentobarbital sodium. In both these combinations, more satisfactory anesthesia was obtained, not only with extensively low dosage of Ketamine hydrochloride or of Pentobarbital sodium, but with less undesirable reactions, characteristic in these two anesthetic agents.
Being specific with these combined anesthesia, was that the effective post-anesthetic sedation was retained for rather long period, even after fairly rapid disappearance of anesthetic effects.
