Abstract
Sixteen dogs with a variety of malignant tumors were treated with low-dose cisplatin(CDDP) as adjuvant chemotherapy after surgery. The dogs were given cisplatin intravenously(I.V.) at a dosage of 20-30mg/m2of body surface area at 2-or3-week intervals. CDDP was administered in the following manner: Saline(0.9% NaC1) at 10-20ml/kg/h was administered for 1 hour. CDDP diluted with saline was then administered I.V. over 1 hour after administration of metoclopramide hydrochloride S.C. and butorphanol tartrate I.V. or S.C. After CDDP administration, another saline infusion(10-20ml/kg/hour) was continued for 30 minutes or 1 hour. The dogs received a total of 110 doses of cisplatin, with an average dose of 24.2mg/m2and the median number of doses of six(range, 3-15 times), and the median cumulative dose was 145mg/m2(range, 60-320mg/m2). Adverse events were seen in 10 of 16 cases, including six vomiting, two anorexia, and two neutropenia. According to the Veterinary Co-operative Oncology Group classification of chemotherapy side effects from grades I to V, these cases were mild(grade I to II), and none of the dogs required hospitalization. These results suggest that low-dose CDDP therapy was a safe method of adjuvant chemotherapy after malignant tumor resection, though further study with a larger number of cases is needed.
