Abstract
The sevoflurane-sparing effect of constant rate infusion (CRI) of lidocaine during surgery was evaluated in 52 dogs. All dogs were premedicated with an intravenous injection (Ⅳ) of propionyl-promazine (0.05 mg/kg) and subcutaneous injection of carprofen (4 mg/kg). Anesthesia was induced with propofol (6 mg/kg Ⅳ) and maintained with inhalation anesthesia using 50% nitrous oxide, 50% oxygen, and sevoflurane. Twenty-six dogs received lidocaine CRI (3 mg/kg/hr) during anesthesia (LID-CRI group) and the other 26 dogs did not (control group). The end-tidal concentration of sevoflurane required to maintain surgical anesthesia was significantly smaller in the LID-CRI group compared with the control group (1.6% vs 2.1%, P ＜0.001). There was no significant difference in the parameters of cardio-respiratory functions during anesthesia between the groups. In conclusion, lidocaine CRI provides a sevoflurane-sparing effect during surgery in dogs without apparent cardio-respiratory depression.
