2012 Volume 65 Issue 8 Pages 597-600
This study was performed to evaluate the effects of Cyclooxygenase-2 inhibitor on equine gastric mucosa. Six healthy thoroughbred horses each received saline (20 ml), phenylbutazone (4.4 mg/kg), firocoxib (5.0 mg/kg), and a combination of omeprazole and phenylbutazone (1.0 and 4.4 mg/kg, respectively) perorally once a day for 7 days with a 14-day washout period between treatments. Gastric mucosa was evaluated using gastric endoscopy before and seven days after treatment. In phenylbutazone treatment, an ulcer of 2.0 cm in diameter was observed in margo plicatus, and the ulcer score increased significantly at day 7. With the other treatments, the ulcer score did not change. These results indicate that the omeprazole has a preventive effect on gastric ulcer induced by phenylbutazone, and firocoxib has less effect on equine gastric mucosa than phenylbutazone does.
