2016 Volume 69 Issue 7 Pages 405-409
A study was carried out of the clinical and pathological features of five bovine cases of adenocarcinoma of the endometrium that were detected retrospectively at the Meat Inspection Station, Kanagawa Prefectural Government over sixteen years. All five cases were Holstein cows, and the average age was 5.8 years old. Grossly, in the progressed cases, the uterine horn and uterine body wall were diffusely thickened and had hardened. Cratered depressions were observed in four cases on the surfaces of the uterine tumors, and constriction of the uterine horn was observed in one case. All five cases had metastases, of which three cases had disseminated metastases. Microscopically, the uterine tumors formed a duct-like configuration in the abundant connective tissue in four cases, but not in one case. Immunohistologically, tumor cells in all five cases were positive for cytokeratin, but negative for vimentin. Induration of the uteri by rectal palpation was observed in two of the three cases examined, which finding might be helpful for the antemortem diagnosis of bovine cases of adenocarcinoma of the endometrium, depending on the disease progression.
