Abstract
At 8, 10, or 15 days of age, 35 puppies from 10 litters were given piperazine adipate in such doses as equivalent to 100 to 400mg/kg of piperazine hydrate in order to examine the anthelmintic effect of the drug on immature dog ascarids.
When administered to puppies at 10 days of age, doses of 100, 200, and 250mg/kg showed no sufficient effect, but doses of 300, 350, and 400mg/kg exhibited an excellent effect upon the removal of worms at the beginning of the fifth stage. Essentially the same results were obtained when the drug was administered to puppies 8 days old which seemed to have been parasitized with larvae at the end of the fourth stage and to those 15 days old which appeared to have harbored worms at the later period of the fifth stage.
It seemed that the larger a worm in size, the more sensitive the worm was to the drug. No conclusions, however, were drawn with regard to this point.
Growth was not retarded in puppies medicated with a dose of 100 to 250mg/kg, but was retarded a little and transitionally in those given a dose of 300 to 400mg/kg. The drug had a slight side effect.
The results mentioned above seem to indicate that medication with a dose of piperazine adipate equivalent to 300mg/kg of piperazine hydrate displays a satisfactory anthelmintic effect upon immature dog ascarids harbored in puppies 8 to 10 days of age. It is suggested that a smaller dose may be sufficient to bring the similar effect to puppies older than these.
