Experiments on Removal of Parasites from Large Intestine by Intravenous Injection with Phthalofyne

Abstract

Phthalofyne was effective to remove parasitesharbored in the large intestine of the dog at a rate of-69 and 92 per cent when injected into the dog at a dose of 200 and 250 mg/kg (hereinafter expressed as mg for short), respectively.
No side-effect was exhibited in dogs injected with 200mg, except two which had been injected at a higher velocity than the others. Of those injected with 250 mg, emesis, ataxia, and anorexia were manifested by 38.5, 38.5, and 27.3 per cent, respectively, but all of them were so mild as to disappear in a short time. It is desirable, however, to evade the administration of this drug to a rather weakened dog, since dogs infected severely with acariasis or distemper died several days after the medication.
It is also desirable to inject the drug slowly; that is, to spend more than one minute to administer the whole dose.
An injection with 600 mg gave rise to marked emesis and ataxia, which nearly disappeared after about 3 hours. An administration of 1, 000 mg killed dogs in several hours. Body temperature decreased strikingly in the animals given 600 or 1, 000 mg.
No noticeable changes occurred to any one of the medicated animals in body temperature at the time of injection, or hematological findings and blood pressure after the injection.