Antibacterial Property of Tyamulin against Mycoplasma Originated from Respiratory Organs of Various Animals

Abstract

The MIC of tyamulin (TN), an antibiotic of the diterpene group, was studied in comparison with tylosin, spiramycin, tetracycline, and chlortetracycline. It was 0.01-0.1μg/ml to Ureaplasma, showing that TN had a higher antibacterial ability than the other four drugs. It was 0.1-2.5μg/ml to Mycoplasma dispar, being almost the Same as that of any other drug.
The MIC of TN was 0.01-0.05μg/ml to Mycoplasma hyopneumoniae of porcine origin, indicating that TN had a slightly higher antibacterial ability than tylosin. It was 0.01-0.025μg/ml to Mycoplasma gallisepticum of avian origin, exhibiting that the antibacterial ability of TN was almost the same as that of tylosin or spiramycin and distinctly higher than that of chlortetracycline.