Chromosome Abnormality in Porcine Lymphosarcoma

Abstract

In-vivo, direct-preparation examinations were conducted on chromosomes from tumor cells of the multicentric type (10), the alimentary type (6), and the thymic type (2), all of which had been diagnosed as porcine lymphosarcoma. The multicentric types were classified as normal (3), nonclonal abnormal (1), and clonal abnormal (6-1 addition type, 2 translocation types, 1 partial addition type, and 1 translocational/multiple type). The alimentary types were classified as 4 nonclonal types and 2 clonal abnormal types (1 deletion type and1 multiple type). The thymic types were classified as 2 clonal types (1 duplication of the addition and partial addition type and 1 translocation partial deletion type). Although no chromosomal abnormality agreeing with anatomical classification was found, apparently, while chromosomal abnormality occurs before and during transformation to the next chromosomal type, clonal abnormal cells repeat division and development. These clonal chromosomal abnormalities may be connected with acute change and transformation. Chromosome examination is therefore expected to become a useful aid in diagnosing and classifying lymphosarcoma.