Abstract
Eighty Holstein steers affected with acute respiratory diseases were treated intramuscularly with cefquinome, a fourth-generation cephem antibiotic with a short withdrawal period. Therapeutic effects were compared with those of ceftiofur, a third-generation cephem antibiotic, by the clinical and microbiological standpoints. Pasteurella multocida and/or P. haemolytica, known to be major causative organisms in acute bovine respiratory diseases, were isolated from these steers. No difference was observed in antibiotic therapeutic effects between diseases caused by Pasteurella spp. and those caused by otherbacteria. Cefquinome had a 98.1% clinical efficacy, which is comparable to that of ceftiofur. At reexammation performed 7 days after final administration, no clinical recurrence was observed.
