Abstract
Examination of 17 cases of canine pyometra showed high levels of serum alkaline phosphatase (ALP) activities in 13 animals (the high ALP group) and normal levels in 4 animals (the normal group). Results concerning clinical symptoms and blood examinations for the two groups were compared. More clinical abnormalities were observed in the high ALP group than in the normal ALP group. But, with the exception of hypercholesterolemia in the high ALP group, differences in blood-examination results were obscure. Analysis of serum ALP Isoenzymes in eight individuals from the high ALP group showed that the liver ALP fraction, which was the highest of 3 fractions (liver, bone, corticosteroid-induced), accounted for an average of 88% of overall ALP activity. In two animals, changes in serum ALP activity were observed. Overall serum ALP activity decreased after ovario-hysterectomy. These changes resulted from decreased liver ALP activity.
