2002 Volume 55 Issue 7 Pages 442-445
Interstitial photodynamic therapy (PDT) utilizing a hematoporphyrin derivative (HpD) and an excimer dye laser was performed in 7 cases of spontaneous tumors (6 dogs and 1 cat). HpD was injected intravenously in doses of 5 mg/kg. Forty-eight hours later a laser-proof plastic tube was implanted in the tumor, and an optic fiber was inserted into the tube. A locally made motor device rotated the tip of the optic fiber and caused it to perform alternative movements. Light energy was set at 150 J/cm. In 3 of 6 dogs (1 benign mixed mammarygland tumor and two mastocytomas), tumors disappeared within 2 weeks. In the remaining 3 cases (benign mixed mammary-gland tumor, hemangiosarcoma and malignant melanoma), the necrotic nature of the tumors was histologically recognized upon surgical removal 2 weeks after PDT. In the cat, necrosis was observed at the center of the tumor (mammary carcinoma).
