Abstract
Physical examination of a 9-year-old female Shih-tzu admitted because of depression and head tilt revealed remarkable splenomegaly. Laboratory examinations revealed nonregenerative anemia, thrombocytopenia, and marked leukocytosis with a left shift extending to the promyelocyte. Examination of the bone-marrow aspirate showed hypercellularity composed of maturing granulocytic cell series. No excessive blast or dysplastic change was observed. No disease that could induce leukemoid reaction was detected. On the basis of these findings, the dog was diagnosed as a case of chronic myelogenous leukemia. Although the number of peripheral blood leukocytes decreased after chemotherapy, the dog died of blastic crisis 11 days after initial admission.
