Abstract
A five-year-old male Boston terrier was presented to the hospital with chronic diarrhea. Various medical and endoscopic examinations suggested that the case was an inflammatory bowel disease. Immunosuppressive therapy based on prednisolone was effective in stopping the clinical symptoms. But the symptoms relapsed after the prednisolone dose was reduced. Subsequently, treatment with prednisolone and cyclosporine was performed, but improved efficacy was not observed. When the concomitant drug was changed to methotrexate (intramuscular) from cyclosporine, a gradual decrease in the prednisolone dose was possible without a relapse in the symptoms. A favorable prognosis was achieved also with oral administration of methotrexate.
