Abstract
responses, including a significant decrease in albumin and a marked rise in gamma- andJoeta-globulins. The alpha globulins were reduced and the A/G ratio decreased moremarkeclly in these cases than in uninfected aninnals. The cconcentration of total proteinshowecl a tendency to decrease about 100 days after infection, although hyper-ga, rruma-globulinemia and hypoalbuminernia remain throughout the experimental period.In naturally ittfccted cattle, total protein and a[joha, globtv, lit showed no significan?tdifference in quantity, as compared with uninfected cattle. XV marked rise in gamma andbeta glooulins and a marked decrease in albumitt were ooservecl in the former. Espcsciallyin cattle iv?fected with Schistosoma japonicum and Fasciola /tepatica, marked hypo-albunninuemiaand hyper-gamma-globulinemia were observed.Antimony-treated dogs, rabbits, and cattle showed a tendeney that total proteitt anclgamrrta globulin decreased and that albumin ittcreased consiclera.bJy, about 20 to 30 daysafter the ertd of treatmenc, i, e., about the time when eggs were negative in the feces.Such changes in the serum protein fractions as mentioned were observed clearly in rabbits.Suc!m changes 5-n serum pr.ctein as noticed ina dogs, rabbits, and cattle at various pen-icdsof infect on with .S. japonicum proved to be characteristic not of any specific disease but ofthe hosts reacti-on to Schistosoma itnfection and injury whicFu had occurred as a result ofdama, ge induced in tJae intestinal and liver tissues Icy cIeposiLton arxd rruigration of eggs orx, vorms and probaoly by metabolites.Five dogs and 5 rabbits were treated with sodiunt antimony tartraLe at?d then chat-lenged with cercaria, e 100 days after the end of treatment (170 days after initial infectiout).It was connfirnned that no eggs were detected from the feccs at the tirrxe of elastl[cnge.The reirtfectecl dogs and rabbits revealed a more marked decr"ease in albumin arzd 21 moreincrease imn beca, - a, nd garrtm, t-gloouliru concentrations about 50 to 60
