EXPERIMENTAL STUDIES ON THE VARIATION OF CARBOHYDRATE IN THE CHICKEN : III. EFFECTS OF CHLORPROMAZINE ON BLOOD GLUCOSE, BLOOD LACTATE, LIVER GLYCOGEN, AND MUSCLE GLYCOGEN

Abstract

Effects of chlorpromazine (CPZ) on the carbohydrate values of male Single-Combed White Leghorn chickens were studied, both in intact and 18-hour fasting conditions. In 18-hour fasting birds, blood glucose showed a slight decrease and either liver or muscle glycogen a slight increase after administration of CPZ. These changes, however, were not statistically significant. In addition to these changes, a decrease in blood lactate was observed, which was statistically significant (P<0.01). Body temperature dropped gradually to approximately 39.6°C. Intact birds exhibited a marked decrease in blood glucose after CPZ administration. Liver glycogen increased 10 minutes after administration. Reversely, the increased level dropped 10 and 20 minutes thereafter. These changes in blood glucose and liver glycogen were statistically significant (0.01<P<0.05). Blood lactate and muscle glycogen revealed a slight increase, which was not statistically significant.