Abstract
A case of general cutaneous papillomatosis in Japanese serow, a wild animal naturally reserved by law (a special natural monument), was reported. Histological observation revealed fibrous proliferation with papillary extention in the dermis, acanthosis with marked vacuolation of epithelial cells and hyperkeratosis. Electron microscopy disclosed vacuolated cytoplasm with scanty tonofibriles in some of the epithelial cells proliferated in the spinosum layer, and virus-like particles in the nucleus of degenerated cells in the corneal layer through the middle spinosum layer. The particles were spherical and measured about 30nm in diameter, and occasionally arranged in a crystalline array. According to the findings obtained, they were possibly identical to a member of the papovavirus group. Discussion was made in comparison with papillomatosis in the other animal species reported previously. Besides, bundles of needle-like filamentous structures were detected in the nucleus in several spinosum layer cells. Lung worms, Protostrongylus Shiozawai (Ohbayashi et Ueno, 1974) were observed in pulmonary sections histologically.
