Abstract
In male spontaneously hypertensive rats fed an atherogenic diet and treated with vitamin D2 (320, 000 I.U./kg/day) for 4 days, arteriosclerosis of Monckeberg type was produced in the aorta with multiple massive hemorrhage in the periaortic adipose and subdural tissues. The production of vascular changes and hemorrhages was inhibited by oral administration of a calcium antagonist, diltiazem (60 mg/kg-twice/day) for 7 days starting at the first day of vitamin D2 treatment.
