Abstract
The livers of the male ddY mice having received repeated intraperitoneal injections of sterile swine serum were examined pathologically. The characteristic changes were eosinophilic and homogeneous or needle-shaped materials in the cytoplasm of biliary epithelial cells. Electron microscopically, the homogeneous material appeared moderately electron dense and amorphous being deposited in remarkably dilated rough-surfaced endoplasmic reticulum, while the needle-shaped one was quadrate in overall shape showing striated crystalline arrays at high magnification.
