Granular Cell Tumor in the Cerebellar Meninx of an Aged Rat

Abstract

A granular cell tumor was found in the leptomeninges of the cerebellar vermis of a male 21-month-old Wistar rat. Histologically, the neoplastic cells which proliferated in sheet and nest fashions frequently showed pleomorphic contour and contained PAS-positive granules in their cytoplasm. Ultrastructurally, the tumor cells had the characteristics of a granular cell tumor. Electron-dense bodies in the cytoplasm of the tumor cells sometimes contained a few rough endoplasmic reticula and ribosomes. Some junctional complexes were present between two adjacent cells.