1986 Volume 48 Issue 3 Pages 599-602
An experiment was carried out to clarify the humoral antibody and cell mediated immune responses of calves experimentally infected with Babesia ovata or Theileria sergenti. Two Holstein calves were inoculated with erythrocytes containing B. ovata or T. sergenti, respectively. They were also splenectomized 12 weeks after inoculation. Throughout the experimental period, they were subjected to general blood tests and examined for macrophage migration inhibitory factor (MIF) activity, IgM and IgG antibody titers, and the microbicidal activity of macrophages. As a result, strong humoral antibody and cell mediated immune responses were noticed 1-3 weeks after inoculation with both protozoa. Of the humoral antibodies, IgM antibody was detected throughout the observation period in the experiment.
