Abstract
Fifteen neurons in the subfornical organ (SFO) were antidromically activated by electrical stimulation of the supraoptic nucleus (SON) of the hypothalamus in urethane-anesthetized rats. Microiontophoretically (MIPh) applied angiotensin II (AII) excited the activity of all identified SFO neurons and the effect of AII was blocked by MIPh-applied saralasin (Sar), an AII antagonist. Intravenously administered AII excited the activity of most (n=13) of these identified SFO neurons and this exciting effect by intravenous AII was also blocked by MIPh-applied Sar.
