Identification of Desmethyl Metabolite of Sulfadimethoxine in Chicken Excreta

Abstract

An unknown metabolite of sulfadimethoxine (SDM) in chicken excreta was identified as N¹-(2-methoxy-6-hydroxy-4-pyrimidinyl) sulfanilamide by mass spectrometry, infrared spectroscopy, and etc. It was found to be a principal metabolite in the excreta of chicken that received SDM and considered as the causal substance of the nonlinear pharmacokinetics of SDM in chicken. This is the first report, in which the compond is identified as the major metabolite of SDM.