A treatment apparatus using atmospheric-pressure plasma was newly developed to treat the inner-surface of tube connectors for medical use. Improving the structure of opposed coaxial electrodes and applying time-modulated RF power between the electrodes enabled uniform inner-surface treatments that did not necessarily need rare gas. In the treatments using nitrogen or helium, the contact angle of water droplets lower than 20 deg was obtained. The mechanism of the good hydrophilic property was discussed using the results of optical emission spectroscopy of plasma, x-ray photoelectron spectroscopy and contact angle of water droplets on a treated surface.