Design of cell-recognizable biomaterials and control of interface physical properties - for application to regenerative medicine -

Abstract

Biomaterials are rapidly being developed as powerful artificial microenvironments to control not only various differential cells but also various stem-cells fate, such as proliferation and differentiation. Our recent advances include biomaterial-based artificial extracellular matrix formed by immobilizing cell-recognizable molecule, growth factors and cytokines. Here, we propose "Cadherin-Matrix Engineering" for new frontier of cell-recognizable biomaterials for construction of "Cell-cooking plate" for ES/iPS cells technology using chimeric proteins of cell adhesion molecules (e.g., E-cadherin, N-cadherin, or VE-cadherin) and biohybrid organs.