Evaluation of sensitivity enhancement of biological phospholipids using carbolic acid matrix in Bi-cluster SIMS

Abstract

In TOF-SIMS measurements, it is difficult to detect the intact ions of macromolecules because the detection limit of that tends to be lower than that of small molecules. Matrix enhanced SIMS is one of the sensitivity enhancement techniques of organic molecules. In this study, we investigated the sensitivity enhancement of phospholipids using aliphatic carbonic acid matrix in TOF-SIMS.