A Screening Study of Mutagen Formation Potential (MFP) of Pesticide Transformation Products in Water Environments (PTPWs) to Investigate the MFP Changes from their Parent Pesticides through Transformations

Hirokazu TAKANASHI; Tomohiro HAMA; Tsunenori NAKAJIMA; Akira OHKI; Takashi KONDO; Takashi KAMEYA; Taku MATSUSHITA

doi:10.2965/jwet.2014.25

原著論文

A Screening Study of Mutagen Formation Potential (MFP) of Pesticide Transformation Products in Water Environments (PTPWs) to Investigate the MFP Changes from their Parent Pesticides through Transformations

Hirokazu TAKANASHI, Tomohiro HAMA, Tsunenori NAKAJIMA, Akira OHKI, Takashi KONDO, Takashi KAMEYA, Taku MATSUSHITA

著者情報

Hirokazu TAKANASHI
Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, Japan
Tomohiro HAMA
Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, Japan
Tsunenori NAKAJIMA
Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, Japan
Akira OHKI
Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, Japan
Takashi KONDO
Division of Natural Environment and Information, Faculty of Environment and Information Sciences, Yokohama National University, Japan
Takashi KAMEYA
Division of Natural Environment and Information, Faculty of Environment and Information Sciences, Yokohama National University, Japan
Taku MATSUSHITA
Department of Environmental Engineering, Faculty of Engineering, Hokkaido University, Japan

キーワード: Ames test, 3-hydroxybenzyl alcohol, iprobenfos, mutagenicity

ジャーナルフリー

2014 年 12 巻 1 号 p. 25-32

DOI https://doi.org/10.2965/jwet.2014.25

詳細

抄録

The mutagenicity of one pesticide and 20 pesticide transformation products in water environments (PTPWs), the mutagen formation potential (MFP) of three pesticides and 28 PTPWs were investigated with the Ames Salmonella mutagenicity assay. The mutagenicity of 2-hydroxybenzyl alcohol (a PTPW of iprobenfos) was positive before chlorination. Out of 28 PTPWs, 18 were positive for the MFP. The difference of the MFP distributions between the parent pesticides and their PTPWs was tested statistically, indicating no increase in the MFP through the transformations. Of the 28 couples of parent pesticides and their PTPWs tested, seven couples increased their MFP through the transformations. The greatest ratio of the increase was 38, which was observed for iprobenfos and its PTPW 3-hydroxybenzyl alcohol.

責任著者(Corresponding author)

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