On Japanese Encephalitis in 1955, Especially with Reference to the Therapy with PANS-610 TW

Abstract

The mode of incidence was discussed of the encephalitis cases experienced in Kitatama district in 1955.
A table, representing the clinical symptoms in scores, was proposed by the author to facilitate a distinct grading of clinical symptoms.
The therapeutic effect of PANS-610 TW (4-acetylamino-naphthalene-1-lauroyl sulfonamide+Tween 80) on encephalitis was examined and its use was recommended by the author. The average mortality rate of encephalitis from 1948 to 1954 was 29.4%, while that in 1955 was reduced to 16.1%, owing to the effect of PANS-610 TW.
The medicament was given to the encephalitis patients until the fever began to fall, 3 or 4 times daily in a dosage of 8 mg/kg at each time. The disappearance of neurological symptoms was accelerated by the medicament, compared with the control group. The effects on the cases, in which the symptoms were represented by more that 13 in the score table, were not so impressive. The final results, however, demonstrated a favourable effect of the treatment in reducing the mortality rate even in such cases in which sequelae were anticipated if recovery took place.
A favourable effect of chlorpromazine was confirmed in suppressing vomiting and convulsion.
The author further reported an incidence of encephalitis for successive 3 years in a family.