Histopathological Studies of the Reduced Side Effects of an Antiviral Chemotherapeuticum, PANS No.610, by Tween 80
1956 Volume 30 Issue 1 Pages 43-47
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1956 Volume 30 Issue 1 Pages 43-47
The injection of Pans No.610 into the auricular vein of rabbits caused paralysis and marked dilatation of the vein. The permeability of the local vessels was increased consequently, causing edema and hemorrhage in the surrounding tissue, and with thrombus formation. On rare occasions thrombophlebitis with leukocytic infiltration was observed as a maximum lesion of this kind.
The addition of Tween 80 to PANS No.610 inhibited the angioparetic effect of PANS No.610 remarkably, and reduced the resulting changes described above.
Visceral organs of rabbits injected with PANS No.610 intravenously did not show so marked histopathologic changes as those seen in and around the auricular vein. Hemoglobin casts were noticed in the kidneys of an animal in the group, to which PANS No.610 was injected. Such changes were not induced by the medicament with additional Tween 80.
