Clinical and Experimental Studies on the Drug-sensitivity of Dysentery Bacilli
I. Change of Drug-sensitivity of Dysentery Bacilli during the Past 5 Years
1959 Volume 32 Issue 12 Pages 903-915
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1959 Volume 32 Issue 12 Pages 903-915
Minimal growth-inhibiting concentrations of six antibiotics, i. e. streptomycin, chloramphenicol, oxytetracycline, chlortetracycline, tetracycline and kanamycin, and a sulfadrug, sulfadiazine, to dysentery bacilli isolated from 1953 to 1957, were investigated using agarplate method in the case of antibiotics, and using the broth method in the case of sulfadiazine, respectively.
The results were as follows:
1) There was no tendency of the sensitivities of dysentery bacilli to antibiotics going down gradually year by year but highly drug-resistant strains were isolated in 1953, 1955, 1956 and 1957. Sensitivity to sulfadiazine of dysentery bacilli was approximately constant.
2) Sensitivities to antibiotics of dysentery bacilli isolated in U.S.A. in and before 1953 were slightly higher than those isolated in Japan in 1954. Fifteen of 23 strains (65%) of dysentery bacilli isolated in U.S.A., 5 of 11 strains (45%) isolated in Korea in 1954, but only 20%(5 of 28 strains) of dysentery bacilli isolated in 1954, were sensitive to sulfadiazine.
3) The number of Sh. fl. 2b decreased, but the number of Sh. fl. 2a, 3a and Sh. sonnei increased year by year.
4) The method of drug-sensitivity test was discussed.
