Chloromycetin Therapy in Great Doses against Carriers of Typhoid Bacilli

Abstract

Three healthy, carriers of typhoid bacilli and two permanent dischargers after the typhoid fever were treated by the authors with: Chloromycetin in great doses. The biliary duct could not be cleared of the bacilli through rinsement with chloromycetin solution after the gall bladder extirpation in one of the 3 healthy carriers and after the operation of artifitial fistulation of gall bladder in the remaining 2.
One of these 3 patients and 2 permanent dischargers were freed from the bacilli by the administration of Chloromycetin in great doses: 100-200 mg/kg for 3-5 days. The concentration in blood was 40-50 7γ/cc. The side effects, though slight and transitory, were almost missing in combined use of 250 mg Chloromycetin, 2mg Nitrate of VB6, 25 mg nicotinic. acid amide, 5 mg Calcium panthothenate, 0, 38mg folic acid, 0.5 mg VK, 17 VB₁₂ and 75 mg VC.