Experimental Studies on Distemper Virus

II. Inoculation Test of the Mouse-fixed Distemper Virus and/or the Mouse-fixed Measles Virus to Dogs.

Abstract

1) The mouse-fixed distemper viruses cultivated in chickembryo or in mouse-brain were inoculated the twenty dogs which had not yet contracted distemper. The symptoms of canine distemper developed were: fever in 19 dogs, conjunctivitis in 18 dogs, coryza as well as exanthemas or pustules of skin in 18 dogs, diarrhoea and anorexia in 19 dogs, decrease of body weight in all dogs, cough in 7 dogs, pneumonia by autopsy in 10 dogs., slight hard pad in 3 out of 20 dogs.
2) Dogs of same litter were inoculated with the mouse-fixed measles virus (4 dogs) and/or mouse-fixed distemper virus (3 dogs). Most symptoms characteristic to canine distemper developed, especially exanthemas undistinguishable from those of native canine distemper were observed in both groups. But Koplik's spots were not observed.