Studies on the Adenovirus Infection in Infants
IV Neutralisation test of adenovirus infection and distribution of neutralisation antibody against 7 types of adenovirus
1959 Volume 33 Issue 3 Pages 253-259
Details
1959 Volume 33 Issue 3 Pages 253-259
Neutralisation test was carried out against each type of adenoviruses with 13 cases which demonstrated a significant rise of complement fixation test in the convalescence. The distribution of serum anbibody against I-VII types according to monthly age was investigated with 50 cases of sucklings under 2 years of age observed from March to June 1957. The results were as follows
1) The type could be decided in 8 out of 13 cases of adenovirus infection. Three cases were Type II and 5 wre Type III.
2) Type II was found always in acute pharyngitis.
Type III was identified in 4 cases of acute pharyngitis and in one case of acute bronchitis.
3) The antibody titer demonstrated the same fluctuation in all types except IV and VII, i. e. indicating the highest value till 3 months after birth, declining between 6-12 months and increasing again in 13-24 months. Type IV showed no tendency of re-increase even in 13-24 months, though in 7-12 months the same pattern of fluctuation was recognized.
4) As for the number of antibody types, infants under 6 months demonstrated 1 to 7 types, respectively, almost a half possessing more than 3. The majority of infants of 7-12 months possessed one or two types, one case out of them demonstrating no antibody. However, 113 of infants of 13-24 months pessessed more than 3 types of antibody.
