麻疹ウイルスの実験的研究

第2報 ウイルスの猿接種実験

抄録

A 20-40% emulsion of chorio-allantoic membrane and fetus of hen egg infected with mouse-adapted measles virus (Ohki-strain serially passed through mouse brains 22-29 generations) was ultracentrifuged ca 100, 000G and concentrated to 100-200x (LD50: 10-6.5-10-7/0.02 ml against mouse). The signs and symptoms similar to the human measles were caused in the monkeys (M. irus 5, M. fuscatus 1, M. mulattus 1) without any experience of measles infection, when injected with 0.6-4 cc/kg of the above mentioned emulsion.
The erruption comparable with the human one was recognized in all the monkeys. except one, killed at the time where enanthem appeared on the mucous membrane. All of the monkeys showed fever and enanthem on the mucous membrane which was, entirely identical with the Koplik's spot in 3 of them. The incubation, the time period. from the injection to the appearance of Koplik's or other spots on the mucius membrane was 6-10 days (average 8 days), and the time period from the injection to the appearane of rash was 12-14 days (average 12 days). The leucocyte count increased in the early incubation period and decreased before or at the height of the disease. The majority of the monkeys demonstrated conjunctivitis, rhinitis and anorexi4, and some of them suffered also from diarrhoea, bronchitis, etc.