Studies on the Serum-Muco-Protein in Scarlet Fever
1960 Volume 34 Issue 1 Pages 52-62
Details
1960 Volume 34 Issue 1 Pages 52-62
In recent years an increasing attention has been payed to the appearance and shift of reactive substances in the acute stage as indicators for the process of infectious diseases which are of prognostic and also therapeutic value by serving for the decision of therapeutic methods. Serum-muco-protein was mesured by the author together with CRP and blood sedimentation rate with 44 scarlet fever patients.
Material of investigation:
Scarlet fever patients admitted to our hospital from October 1958 to March 1959 were divided into two groups; non-treated (26 cases) and treated group (18 cases).
Technics:
For serum-MP, tyrosine was measured by Winzler method, CRP by Anderson-McCarty method and blood sedimentation rate by Westergren method.
Results:
1. MP of all the 26 cases of non-treated group rose over the nomal value in the initial stage of the disease, increased still more until the middle of the 2nd week and decreased gradually until the end of the 4th week.
2. MP of all the 18 cases of the treated group rose over the normal value in the initial stage of the disease, increased until the 5th day, decreased from the 6th day, and approached again to the normal value in the 2nd week, but demonstrated a similar shift as the non-treated group from the 3rd week on.
3. The shift of serum-MP showed a remarkable difference between the treated and non-treated group, indicating an effect of the therapy.
4. In the cases which still demonstrated a high serum-MP value, persistence of pharyngeal streptococcus hemolyticus and a complication might be considered.
5. In the initial stage CRP was positve in all the cases of both groups. Thereafter it turned gradually to negative from the 11th to 26th bap in the non-treated group, but became abruptly negative in the treated group.
6. The positive rate of CRP and the grade of its reaction became higher with the increase of serum-MP value.
7. The blood sedimentation rate of both groups accelerated by 40-60% in the initial stage, increased still more until the end of the 1st week and gradually came down to the normal value. In the trated group, however, it tended to become normal earlier than in the non-treated group.
