Adrenaline Sensitizing Property of Various Bacterial Substances by Means of Krawkow-Pissemski's Technique

Abstract

According to the Krawkow-Pissemski's technique, blood vessel preparation of rabbit's ear was used in order to study the influence of pretreatment with various bacterial substances on the vasoconstrictive effect of adrenaline.
As Bacterial substances, their endotoxin or polysaccharide-fraction was mainly used. Among 22 strains of Shigella dysenteriae or sonnei, Escherichia coli, Salmonella typhi, Salmonella Potsdam, Pneumobacillus, Mycobacterium tuberculosis and Saccharomyces cerviciae, bacterial substances derived from 4 of 14 strains of Shigella dysenteriae, 1 of 3 strains of Escherichia coli and one strain of Salmonella Potsdam exhibited the adrenaline sensitizing effect.
The polypeptide-fraction from these bacterial substances did not exhibit such an effect.
The endotoxin or bacterial polysaccharide derived from Shigella dysenteriae isolated from 4 of 8 “Ekiri-patients” was demontsrated to exert the most powerful such effect.
On the other hand, the substance derived from Shigella dysenteriae isolated from 5 patients of ordinary colitis-type of dysentery exhibited no effect. The strain of Sal monella Potsdam was also isolated from a patient presenting “Ekiri-syndrome”.
These evidences may suggest a correlation of adrenaline sensitizing property of bacterial sudstances and the appearance of “Ekiri-syndrome”.